Rank
|
Symbol
|
Name
|
12/24/2018
|
1/18/2019
|
% Return
|
Market Cap
|
Catalysts
|
1
|
INSM
|
Insmed Incorporated
|
$11.60
|
$23.99
|
106.81%
|
$1.8B
|
Positive Q4 sales outlook for Arikayce
|
2
|
MRTX
|
Mirati Therapeutics Inc
|
$35.74
|
$64.92
|
81.65%
|
$2.2B
|
Announce collaboration with BMY for Phase 3 NSCLC Sitravatinib + Opdivo
|
3
|
LOXO
|
Loxo Oncology Inc
|
$129.40
|
$233.50
|
80.45%
|
$7.2B
|
Acquisition by LLY
|
4
|
EPZM
|
Epizyme Inc
|
$5.36
|
$9.56
|
78.36%
|
$756.8M
|
Seeking accelerated approval of tazemetostat after meeting with FDA
|
5
|
PTLA
|
Portola Pharmaceuticals Inc
|
$15.80
|
$26.53
|
67.91%
|
$1.8B
|
FDA approval of PSA for Andexxa
|
6
|
SAGE
|
SAGE Therapeutics Inc
|
$83.57
|
$139.79
|
67.27%
|
$6.6B
|
Positive results from Phase 3 SAGE-217 for PPD,
|
7
|
ACHN
|
Achillion Pharmaceuticals, Inc.
|
$1.31
|
$2.19
|
67.18%
|
$303.6M
|
|
8
|
NVTA
|
InVitae Corp
|
$9.26
|
$14.94
|
61.34%
|
$1.1B
|
Positive FY18 full year outlook
|
9
|
ARQL
|
ArQule, Inc.
|
$2.42
|
$3.74
|
54.55%
|
$407.6M
|
Partner BSLN positive results from Phase 2 derazantinib for iCCA
|
10
|
OPK
|
Opko Health Inc.
|
$2.46
|
$3.80
|
54.47%
|
$2.1B
|
CEO Phillip Frost reached settlement with SEC
|
11
|
BPMC
|
Blueprint Medicines Corp
|
$46.91
|
$70.02
|
49.26%
|
$3.1B
|
Announced corporate goal by 2020
|
12
|
ACAD
|
ACADIA Pharmaceuticals Inc.
|
$14.32
|
$21.07
|
47.14%
|
$3.0B
|
|
13
|
CELG
|
Celgene Corporation
|
$59.21
|
$86.27
|
45.70%
|
$60.3B
|
Acquisition by BMY
|
14
|
FOLD
|
Amicus Therapeutics, Inc.
|
$8.61
|
$12.31
|
42.97%
|
$2.3B
|
Positive FY19 sales outlook for Galafold
|
15
|
BLUE
|
bluebird bio Inc
|
$91.25
|
$129.96
|
42.42%
|
$7.1B
|
|
16
|
DVAX
|
Dynavax Technologies Corporation
|
$8.49
|
$12.05
|
41.93%
|
$755.4M
|
Positive Q4 sales outlook for HEPLISAV-B
|
17
|
EXAS
|
EXACT Sciences Corporation
|
$56.04
|
$78.80
|
40.61%
|
$9.7B
|
Positive Q4 sales outlook
|
18
|
SGEN
|
Seattle Genetics, Inc.
|
$52.61
|
$73.61
|
39.92%
|
$11.9B
|
|
19
|
FATE
|
Fate Therapeutics Inc
|
$11.51
|
$16.04
|
39.36%
|
$1.0B
|
|
20
|
IRWD
|
Ironwood Pharmaceuticals, Inc.
|
$9.31
|
$12.91
|
38.67%
|
$2.0B
|
Agreement with MYL for generic entrance of Linzess in 2030
|